Cantargia AB today announced the submission of a clinical trial application investigating antibody CAN04 in combination with FOLFIRINOX for first line treatment of metastatic pancreatic cancer . The | …

Cantargia AB today announced the submission of a clinical trial application investigating antibody CAN04 in combination with FOLFIRINOX for first line treatment of metastatic

CAN04 binds interleukin 1 receptor | January 11, 2021 Cantargia AB today announced that the application for a US IND regarding the antibody CAN04 has been submitted to the US FDA. CAN04, an antibody targeting interleukin 1 receptor accessory protein ( Antibody based cancer treatment with multiple functions Cantargia’s antibody-based cancer treatments may eventually change the lives of millions. Focusing initially on lung cancer and pancreatic cancer, the goal is for Cantargia’s lead drug to increase the life span as well as the quality of life in a very large patient group, targeting more cancer diseases as clinical results excel. Anti-drug antibodies (ADA) against CAN04 • Anti-Drug Antibodies (ADA) against CAN04. Preliminary signs of efficacy • Overall Response Rate (ORR) using irRC and RECIST 1.1; with irRC to be the decision-making criteria. • Duration of Response (DoR). • Progression Free Survival (PFS) at 12 months and for the duration of the trial SvD Näringsliv - nyheter inom ekonomi och näringsliv, aktier och börs.

CAN04. Pancreatic cancer. Immuno-. Oncology. Available. Cantargia develops antibody based therapy against the target IL1RAP.

Cantargia AB today announced that the IND application regarding the antibody CAN04 has been approved by the US FDA. CAN04, an antibody targeting interleukin 1 receptor accessory protein (IL1RAP

Actinium is also developing its proprietary AWE (Antibody Warhead Enabling) Our development programme includes the product candidate CAN04, which is has reported positive interim data from the ongoing Phase IIa trial with lead asset CAN04, an anti-IL1RAP antibody targeting the IL-1 pathway Hansa Medical: for the prevention of antibody mediated organ rejection Cantargia. CAN04. Pancreatic cancer. Immuno-.

• CAN04, blocking the activity of both forms of IL-1, increases the efficacy of several different chemotherapy regimes antargia A (“ antargia”) today presented new preclinical data giving additional knowledge around the mechanisms and thereby relevance of adding the clinical stage antibody CAN04 to chemotherapy. CAN04 combined with different

CAN04 is investigated in two clinical trials. The antibody CAN04 binds IL1RAP with high affinity and functions through both blockade of IL-1 signaling and Antibody-Dependent Cellular Cytotoxicity (ADCC). Preclinical data show that CAN04 can increase the efficacy of chemotherapy.

Preclinical data show that CAN04 can increase the efficacy of chemotherapy. 2020-04-07 · The antibody CAN04 binds IL1RAP with high affinity and its anti-tumor activity consists both of stimulation of immune cells to eradicate cancer cells as well as blockade of interleukin 1 signaling. • Anti-Drug Antibodies (ADA) against CAN04. Preliminary signs of efficacy • Overall Response Rate (ORR) using irRC (Part I and Part II Arms A, B, and E), iRECIST (Part II, Arms C and D) and RECIST 1.1 (both Part I and II); with irRC (before protocol version 7.0) or iRECIST (from protocol version 7.0 onwards) to be the decision-making criteria.
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Preliminary signs of efficacy • Overall Response Rate (ORR) using irRC (Part I and Part II Arms A, B, and E), iRECIST (Part II, Arms C and D) and RECIST 1.1 (both Part I and II); with irRC (before protocol version 7.0) or iRECIST (from protocol version 7.0 onwards) to be the decision-making criteria. New phase I clinical data on Cantargia's antibody CAN04 (nidanilimab) were presented today in an oral session at the 2019 ASCO Annual Meeting.

The antibody CAN04 binds IL1RAP with high affinity and functions through both blockade of IL-1 signaling and Antibody-Dependent Cellular Cytotoxicity (ADCC). Preclinical data show that CAN04 can increase the efficacy of chemotherapy.
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Antibody based cancer treatment with multiple functions Cantargia’s antibody-based cancer treatments may eventually change the lives of millions. Focusing initially on lung cancer and pancreatic cancer, the goal is for Cantargia’s lead drug to increase the life span as well as the quality of life in a very large patient group, targeting more cancer diseases as clinical results excel.

CAN04, an antibody targeting interleukin 1 receptor accessory protein (IL1RAP), is currently being investigated for treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC) in phase IIa clinical development. The CAN04 antibody is targeted against IL1RAP, found in a number of cancer forms. The first sites in the phase I/IIa clinical trial CANFOUR have been initiated and patient recruitment is ongoing. According to the protocol, patients are recruited in groups of three. Cantargia’s antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody Dependent Cellular Cytotoxicity and blockade of interleukin 1 signaling. CAN04 is investigated in phase IIa clinical development for non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC). Tumor samples from 15 patients The antibody CAN04 binds strongly to the target IL1RAP and functions both though ADCC as well as blocking IL-1α and IL-1β signaling.